Würmer des Urogenitalsystems
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Print book : German View all editions and formats. Publication: Jenaische Zeitschrift f. Allow this favorite library to be seen by others. Würmer des Urogenitalsystems this favorite library private. Find a copy in the library. Find more information about:. Add a review Würmer des Urogenitalsystems share your thoughts with other readers. Remember me on this computer. Continue reading Saved Searches Home.
Würmer des Urogenitalsystems Urogenitalsystems
Die Verbindung kann hergestellt werden, indem man das Amidin Würmer des Urogenitalsystems Formel II The compound can be prepared by reacting the amidine of formula II mit dem Enamin der Formel III with the enamine of formula III umsetzt. Acts as a solvent, the enamine of formula III. The reaction can be normal, elevated or reduced pressure Runaway results are eg. Im allgemeinen arbeitet man bei Normaldruck. It is generally carried out at atmospheric pressure.
Die Verbindung der Formel II ist neu und daher ein weiterer Gegenstand der Erfindung. The compound of formula Würmer des Urogenitalsystems is novel and therefore a further subject of the invention. Diese stellen daher einen weiteren Gegenstand der Erfindung dar. They therefore represent a further object of the present invention. The conversion of the ester to amide may by saponification with base to acid, carried their conversion to the acid chloride by conventional methods, eg.
The elimination of water from the amide to the nitrile can be carried out with all the usual dehydrating agents. The conversion of the nitrile to the imino ether can take place in an acidic medium such. The presentation of the pyrimidine by conventional methods. Hierbei kann man sowohl vom Iminoether ausgehen und diesen z. Here you can both come from the imino ether and implement these z. However, it is also Würmer des Urogenitalsystems first imino ether with ammonia or its salts converted into an amidine and implement this either as a free base or as a salt with enamines, acetals, enol ethers, aldehydes or enolates.
Bis dimethylamino -tert-butoxymethan, Dialkoxy-dialkylamino-methanen hergestellt werden. The enamines can eg. For example, from CH-acidic compounds such as Acetonitrilderivaten by known methods by reaction http://onshopping.ru/blog/praeparate-aus-wuermern-und-ihre-preise.php dimethylformamide derivatives such.
As bis dimethylamino -tert-butoxymethane be dialkoxy-dialkylamino-methanes produced. These include, for example, alkali metal hydroxides such as sodium hydroxide or potassium hydroxide, alkaline earth metal Würmer des Urogenitalsystems such as barium hydroxide, alkali metal carbonates such as sodium carbonate or potassium carbonate, Würmer des Urogenitalsystems earth metal carbonates such as calcium carbonate.
Preferred is sodium carbonate. Die Verbindung der Formel IV ist neu und daher ein weiterer Gegenstand der Erfindung. The compound of formula IV is novel and therefore a further subject of the invention. Instead of the sodium salt of the enolate also enol ethers, ketones or enamines can be used. The compounds of formulas XIII and XIV are Würmer des Urogenitalsystems and can Würmer des Urogenitalsystems prepared http://onshopping.ru/blog/behandlung-fuer-wuermer-beifuss-und-rainfarn.php customary check this out. The compounds of formulas VVIVIIVIIIIXXXI and XII are new and can be prepared as described above.
The compound of formula I according to the invention has an unforeseeable, valuable pharmacological action spectrum. The compound of formula I according to the invention leads to vasorelaxation, inhibition of platelet aggregation and to a reduction in blood pressure and an increase in coronary blood flow. These effects are mediated by direct stimulation of soluble guanylate cyclase and an intracellular increase in cGMP.
In addition, the compound of the invention enhances the effect of substances which increase the cGMP level, such as EDRF endothelium-derived relaxing factorNO donors, protoporphyrin IX, arachidonic acid or phenylhydrazine derivatives. It can therefore be employed in medicaments for the treatment of cardiovascular diseases Würmer des Urogenitalsystems as for the treatment of hypertension and heart failure, stable and unstable angina pectoris, peripheral and cardiac vascular disorders, arrhythmias, for the treatment of thromboembolic diseases and ischemia such as myocardial infarction, stroke, transitory and ischemic attacks peripheral read more disorders, prevention of restenosis such as after thrombolysis therapy, percutaneous transluminal angioplasty PTApercutaneous transluminal coronary angioplasty PTCAbypass and for the treatment of atherosclerosis and diseases of the urogenital system such as prostate, erectile dysfunction, female sexual dysfunction and incontinence.
In addition, the invention comprises the combination of the compound of the invention with organic nitrates and NO donors. NO-Species ihre therapeutische Wirkung entfalten. Organic nitrates and NO donors in the invention are generally substances that exert their therapeutic effect via release of NO or NO species.
In addition, the invention includes the combination with compounds which inhibit the degradation of cyclic guanosine monophosphate cGMP. To determine the cardiovascular effects following tests were performed: In in vitro tests on cells of vascular origin, the visit web page on guanylate cyclase-dependent cGMP formation was with and without NO donor tested.
Die Würmer des Urogenitalsystems Eigenschaften wurden an mit Kollagen stimulierten menschlichen Thrombozyten Würmer des Urogenitalsystems. The antiaggregatory properties were shown to stimulated with collagen Würmer des Urogenitalsystems platelets. The vasorelaxant effect was determined http://onshopping.ru/blog/worms-ist-in-deutsch.php precontracted with phenylephrine Kaninchenaortenringen.
Die blutdrucksenkenden Wirkungen wurden an narkotisierten und wachen Ratten unter Würmer des Urogenitalsystems. The antihypertensive effects were anesthetized and awake rats examined. Primary endothelial cells from pig by treatment with collagenase soln. For stimulation of endothelial guanylate cyclase, the culture medium was aspirated and the cells were washed once with Ringer solution. Subsequently, the intracellular cGMP-containing supernatants were removed and determines the cGMP concentrations by the cGMP-SPA system Amersham Buchler, Braunschweig.
Rabbits are stunned and exsanguinated by blow to the neck. Zur Erzeugung einer Kontraktion wird Phenylephrin dem Bad kumulativ in ansteigender Konzentration zugesetzt. To produce a contraction, phenylephrine to the bath cumulatively in increasing concentration. After several control cycles, the test substance is investigated in each Würmer des Urogenitalsystems passage in increasing dosage in each case and compared the amount of contraction with the height of the contraction reached in the last preceding run.
After tracheotomy, a catheter is inserted to measure blood pressure in the femoral artery. Dazu waren den Tieren chronisch Druckaufnehmer Data Sciences Inc. These animals were chronically pressure transducer Data Sciences Inc. Paul, MN, USA was implanted in the descending abdominal aorta below the renal artery and was fixed in the abdominal cavity, the transmitter associated with it.
Food and water were freely available. Zur Bestimmung der Thrombozytenaggregation wurde Blut von gesunden Probanden beiderlei Geschlechts verwendet. For the determination of platelet aggregation, blood was used by healthy volunteers of both sexes. The platelets were then centrifuged and taken up in buffer and again centrifuged. Subsequently, the aggregation was initiated by the addition of collagen in an aggregometer and by the turbidimetric method according to Born Born, GVR, J.
It is also suitable for the treatment of diseases of Würmer des Urogenitalsystems central nervous system Würmer des Urogenitalsystems as anxiety, stress and depression, CNS-related sexual dysfunctions and sleep disturbances, and for controlling Würmer des Urogenitalsystems disorders of food, enjoyment and addictive substances.
Furthermore, the active ingredient are also suitable for controlling cerebral blood flow and thus provide an effective means for controlling migraine. He also suitable for prophylaxis and control of sequelae of cerebral infarction happen cerebral apoplexy such as stroke, cerebral ischemia and craniocerebral trauma. Likewise, the compound of formula I according Würmer des Urogenitalsystems the invention can be used to control pain.
The present invention includes pharmaceutical preparations which, besides nontoxic, inert pharmaceutically suitable excipients, the compound of formula I according to the invention and processes for producing these preparations. The active ingredient may optionally be present in one or more of the abovementioned excipients in microencapsulated form.
The pharmaceutical preparations mentioned above can except the inventions to the invention the compound of formula I also contain other active pharmaceutical ingredients. Then it is evaporated in vacuo and the Würmer des Urogenitalsystems distilled under high vacuum.
After cooling, the precipitated sodium trifluoroacetate crystals are filtered off, washed with dioxane and the solution reacted further. Die vereinigten organischen Phasen werden mit Magnesiumsulfat getrocknet und einrotiert. The combined organic layers were dried with magnesium sulfate and evaporated.
The mixture is stirred for two days at room temperature and then click here in vacuo. The mixture is stirred overnight at room temperature. The solvent was evaporated in vacuo, the residue was triturated with acetone, and the precipitated solid von Würmern Methode Dschingis Khan filtered off.
Over two steps Smp. After cooling, the mixture becomes solid. The mixture is stirred with a little toluene, suction filtered and the crystals washed with ether. Of the target compound. Thrombozytenaggregationshemmung in vitro Inhibition of platelet aggregation in vitro Zur Bestimmung der Thrombozytenaggregation wurde Blut von gesunden Probanden beiderlei Geschlechts verwendet.
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Tumoren des Urogenitalsystems on ResearchGate, the professional network for scientists.
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